There are many museums and cultural centers in San Cristobal de las Casas. One major cultural venue is the Cultural Center Museum of the Highlands of Chiapas, located in the former monastery of Santo Domingo. Here there is a series of objects and images that illustrate the most relevant historical aspects of city life. The museum also has a textile and fabric crafts workshop founded by the Tzeltal and Tzotzil indigenous inhabitants of the region.

Another museum in San Cristóbal is the Bolom National Museum or the "Casa del Jaguar." This museum house belonged to the famous Danish anthropologist and philanthropist Frans Blom and his wife Gertrude Blom, who bequeathed his collection of Mayan antiquities, regional handicrafts, and clothing to the community of San Cristóbal de las Casas, so a visit will give one an idea of how the traditions of this place were built based on original pieces.

Another important option is the Sergio Castro and Sons' Museum, which features an extensive collection of textile artifacts and items of the Tzotzil, Tojolabal, and Lacandona indigenous peoples, as well as musical instruments of yesteryear. This is a fun experience, and it will immerse the visitor in the main economic activity of these ethnic groups, which still exist in Mexico.